This differential expression of Robo proteins or "Robo code" provides a complex interplay and regulatory mechanism for cellular interpretation of the repulsive Slit signal. The three robo genes are expressed at different stages of development with unique and overlapping patterns of expression in different cells. Both groups showed that Robo and Robo2 double mutants recapitulate the slit phenotype, and they analyze the expression patterns of the robo genes. and Simpson et al.) have characterized two additional Robo receptors, Robo2 and Robo3, in Drosophila for their roles in controlling neuronal migration and midline crossing and the formation of the longitudinal fascicles. However, Drosophila slit and robo mutants have different phenotypes, suggesting that there may be additional receptors for Slit: slit causes all axons to enter the midline and not leave, robo causes aberrant crossing and recrossing of the midline. Robo (expressed on neurons) and Slit (expressed by midline glia) are a receptor and repulsive ligand, respectively, that help control midline crossing and cellular migration of neurons during development (and mesodermal cells during the development of other organs and tissues).
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